Table of Contents
ISRN Hepatology
Volume 2014, Article ID 846923, 12 pages
Review Article

The Wide and Complex Field of NAFLD Biomarker Research: Trends

1BioPersMed/Biobank Graz, Medical University of Graz, Stiftingtalstrasse 3.1, Graz, 8010 Styria, Austria
2Siemens AG Austria, Corporate Technology, Biosensors, Strassganger Strasse 315, Graz, 8045 Styria, Austria

Received 6 January 2014; Accepted 19 February 2014; Published 28 April 2014

Academic Editors: N. Mendez-Sanchez, L. Miele, and M.-L. Yu

Copyright © 2014 Erika Wichro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Nonalcoholic fatty liver disease is now acknowledged as a complex public health issue linked to sedentary lifestyle, obesity, and related disorders like type 2 diabetes and metabolic syndrome. Aims. We aimed to retrieve its trends out of the huge amount of published data. Therefore, we conducted an extensive literature search to identify possible biomarker and/or biomarker combinations by retrospectively assessing and evaluating common and novel biomarkers to predict progression and prognosis of obesity related liver diseases. Methodology. We analyzed finally 62 articles accounting for 157 cohorts and 45,288 subjects. Results. Despite the various approaches, most cohorts were considerably small and rarely comparable. Also, we found that the same standard parameters were measured rather than novel biomarkers. Diagnostics approaches appeared incomparable. Conclusions. Further collaborative investigations on harmonizing ways of data acquisition and identifying such biomarkers for clinical use are necessary to yield sufficient significant results of potential biomarkers.