Factors Determining Survival and Retention among HIV-Infected Children and Adolescents in a Community Home-Based Care and a Facility-Based Family-Centred Approach in Kampala, Uganda: A Cohort Study
Table 2
Factors associated with attrition among HIV-infected children and adolescents on ART in a community home-based care model and a facility-based family-centred approach, Kampala, Uganda, (2003–2010) using Cox regression.
Characteristics
Unadjusted (univariate analysis)
Adjusted* (multivariate analysis)
HR‡ (95% CI)
HR‡ (95% CI)
Model of care
FBFCA
1
0.002
1
0.006
CHBC
0.40 (0.23–0.70)
0.29 (0.12–0.70)
Age (months)
<12
1
1
12–35
0.73 (0.31–0.70)
0.465
1.95 (0.39–9.89)
0.419
36–59
0.29 (0.09–0.87)
0.028
1.63 (0.18–15.17)
0.664
60+
0.43 (0.22–0.85)
0.015
3.19 (0.27–37.03)
0.354
Gender
Female
1
0.675
Male
1.13 (0.64–1.99)
Cd4 count and percent
CD4†
0.86 (0.69–1.06)
0.162
CD4%†
1.00 (0.57–1.77)
0.992
Level of immunosuppression by CD4
Not significant
1
1
Mild
4.17 (1.31–13.31)
0.016
4.66 (1.21–17.98)
0.026
Advanced
0.87 (0.16–4.73)
0.868
0.89 (0.09–9.12)
0.921
Severe
3.14 (1.10–8.94)
0.032
3.16 (0.81–12.39)
0.099
Age at ART initiation
Months†
0.74 (0.61–0.90)
0.003
0.67 (0.31–1.44)
0.309
WHO clinical staging
I-II
1
0.309
III-IV
1.52 (0.68–3.38)
Growth response Weight-for-age
≤−2SD
1
0.006
1
0.002
>−2SD
0.40 (0.21–0.77)
0.31 (0.15–0.65)
Height-for-age
≤−2SD
1
0.060
>−2SD
0.54 (0.28–1.03)
Hazard of attrition; †log transformed due to skewed data;
*only factors significant at univariate or borderline were considered into multivariate.
