Table of Contents
International Scholarly Research Notices
Volume 2014 (2014), Article ID 853697, 8 pages
http://dx.doi.org/10.1155/2014/853697
Research Article

Protective Effect of Curcumin against the Liver Toxicity Caused by Propanil in Rats

1Department of Chemical Sciences, Redeemer’s University, PMB 2011, Mowe, Ogun, Nigeria
2Department of Pharmacology, College of Medicine, University of Lagos, PMB 12003, Lagos, Nigeria

Received 30 June 2014; Revised 28 July 2014; Accepted 19 August 2014; Published 29 October 2014

Academic Editor: Virinder S. Parmar

Copyright © 2014 Chiagoziem A. Otuechere et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We investigated the protective effects of curcumin on propanil-induced alterations in biochemical indices in blood and liver of male Wistar rats. The study consisted of four treatment groups, with six animals each, designated as control, propanil (20mg/kg), curcumin(50 mg/kg), and curcumin (50 mg/kg) + propanil (20 mg/kg). Rats were administered their respective doses orally, every other day, for 28 days. Propanil administration elicited significant () increases in plasma aspartate aminotransferase and alkaline phosphatase activities, by 24% and 56%, respectively, compared to the control. Treatment with propanil elevated bilirubin, creatinine, and total cholesterol levels in rats, but these were not significant relative to controls. Administration of propanil to rats significantly () increased lipid peroxidation levels. However, catalase activity, vitamin C, and reduced glutathione levels were significantly reduced. Exposure to propanil did not produce any significant changes in packed cell volume, neutrophils, and leukocyte counts. The supplementation of curcumin attenuated the adverse effects of propanil intoxication by reducing lipid peroxidation levels and restored the levels of serum enzymes and reduced glutathione. The present study showed that propanil increased oxidative stress and altered some biochemical parameters in the rats but curcumin could afford some protection to attenuate propanil-induced toxicity in the liver.