Table of Contents
ISRN Organic Chemistry
Volume 2014 (2014), Article ID 894250, 8 pages
Research Article

Antimicrobial and Dyeing Properties of Reactive Dyes with Thiazolidinon-4-one Nucleus

1Department of Chemistry, College of Natural and Computational Sciences, Haramaya University, P.O. Box 276, Haramaya, Ethiopia
2Department of Chemistry, College of Natural and Computational Sciences, Mekelle University, Ethiopia
3Department of Chemistry, College of Natural and Computational Sciences, Assosa University, Ethiopia

Received 19 December 2013; Accepted 14 January 2014; Published 4 March 2014

Academic Editors: P. S. Andrada and H. G. Bonacorso

Copyright © 2014 Hailemichael Ayalew et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Four imines, the condensation products of 2,4-dioxo-4-phenylbutanal with four primary amines, were condensed with mercapto acetic acid to obtain thiazolidinon-4-ones which on subsequent condensation with vanillin and isatin separately yielded eight thiazolidin-4-one derivatives. The chemical structures of the synthesized compounds were elucidated by elemental analysis, molecular weight determination, IR and 1H and 13C NMR spectral measurements. Antibacterial and antifungal properties were studied in vitro against two bacteria and two fungi. The dyeing potential of synthesized reactive dyes was investigated with regard to silk, wool, cotton, and polyester fabrics under hot and cold dyeing conditions.