Inflammatory Response in Patients under Coronary Artery Bypass Grafting Surgery and Clinical Implications: A Review of the Relevance of Dexmedetomidine Use

<table>Cardiopulmonary bypass neutrophil activation. At neutrophil activation by inflammatory mediators a neutrophil rolling phase occurs, with posterior endothelial adhesivity, initially light, then firmly, resulting in the neutrophil-endothelial transmigration. It leads to neutrophil accumulation, reactive oxygen species (ROS) production, and cytokine release, maintaining the vicious circles. CPB: cardiopulmonary bypass; PMN: polymorphonuclears; ROS: reactive oxygen species; ICAM: intercellular adhesion molecule; PECAM: platelet/endothelial cell adhesion molecule.</table>

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Figure 2: Inflammatory Response in Patients under Coronary Artery Bypass Grafting Surgery and Clinical Implications: A Review of the Relevance of Dexmedetomidine Use 

Figure 2 | Inflammatory Response in Patients under Coronary Artery Bypass Grafting Surgery and Clinical Implications: A Review of the Relevance of Dexmedetomidine Use 