Research Article

Antinociceptive Effects of the Serotonin and Noradrenaline Reuptake Inhibitors Milnacipran and Duloxetine on Vincristine-Induced Neuropathic Pain Model in Mice

Figure 1

Vincristine (VCR; 0.025–0.1 mg/kg, i.p.) or saline was administered once per day for 7 days (days 0–6) to mice. (a) On day 14, the withdrawal responses to mechanical stimulation using a von Frey filament (0.4 g) were measured. (b) Time course of vincristine-induced mechanical allodynia. The withdrawal responses to mechanical stimulation using a von Frey filament (0.4 g) were measured on days 0 (Pre), 1, 3, 7, 10, 14, 21, 28, and 35, prior to daily vincristine administration. Data are presented as mean ± S.E.M. for 10 mice in each group. Significant differences between the groups were assessed with one- or two-way ANOVA followed by Dunnett’s test (a) or Bonferroni’s test (b), respectively. compared with the saline control group.
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(a)
915464.fig.001b
(b)