Alginate Particles as Platform for Drug Delivery by the Oral Route: State-of-the-Art
Figure 12
Oral delivery of pDNA with GFP reporter in ALG microspheres in mice. (a) Flow cytometric analyses showing biodistribution reflected through %GFP-positive cells among various organs 24 and 48 h after the administration of 50 μg and 100 μg pDNA dose. Number of animals for each dose ; total number of . (b) Dose-response assessment showing %GFP-positive cells among various mice organs 24 h after the administration of 50 μg, 100 μg, and 150 μg dose. Number of animals for each dose (except for 150 μg-dose group which had only 3); total number of . All measurements were done in triplicates. Results represent error with the basal levels of expression from negative controls subtracted from expression levels observed in dosed groups. Reproduced from [130] with permission of Elsevier.
