Table of Contents
International Scholarly Research Notices
Volume 2014, Article ID 965235, 9 pages
Review Article

Corticosteroid Treatment Impact on Spinal Deformity in Duchenne Muscular Dystrophy

1Section of Orthopedics and Traumatology, University of Messina, 98125 Messina, Italy
2Laboratory of Musculoskeletal Cell Biology, Rizzoli Orthopedic Institute, IRCCS, 40136 Bologna, Italy
3General Orthopedic Surgery, Rizzoli-Sicilia Department, Rizzoli Orthopedic Institute, Bagheria, 90011 Palermo, Italy

Received 21 June 2014; Accepted 24 August 2014; Published 30 October 2014

Academic Editor: Katherine Athayde Teixeira de Carvalho

Copyright © 2014 Ilaria Sanzarello et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Duchenne muscular dystrophy is a progressive disease with loss of ambulation at around 9-10 years of age, followed, if untreated, by development of scoliosis, respiratory insufficiency, and death in the second decade of life. This review highlights the natural history of the disease, in particular, with regard to the development of the spinal deformity and how this complication has been modified by surgical interventions and overall by corticosteroid treatment. The beneficial effect of corticosteroids may have also an impact on the clinical trial design of the new emerging causative therapies.