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International Scholarly Research Notices
Volume 2014, Article ID 967091, 7 pages
Clinical Study

Comparative Study on the Efficacy of Anorganic Bovine Bone (Bio-Oss) and Nanocrystalline Hydroxyapatite (Ostim) in Maxillary Sinus Floor Augmentation

1Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz 5166614711, Iran
2Department of Anatomy and Histology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz 5166614711, Iran
3Department of Periodontics, Tabriz Dental Faculty, Tabriz 5166614711, Iran

Received 24 June 2014; Accepted 31 August 2014; Published 30 October 2014

Academic Editor: David Wray

Copyright © 2014 Adileh Shirmohammadi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. The aim of this study was to evaluate the efficacy of anorganic bovine bone (Bio-Oss) in comparison with nanocrystalline hydroxyapatite (Ostim) in sinus floor augmentation. Methods. Ten patients aged 40–80 were selected. All the patients needed sinus floor augmentation due to insufficient bone for simultaneous implant placement. The patients underwent panoramic radiography and cone beam computed tomography (CBCT) prior to surgical procedure. After lifting the sinus membrane, Bio-Oss and Ostim are randomly grafted at one of the two sides. Biopsies were obtained from areas identified 5 months after the surgery and before implant placement and then were prepared for histological analysis. Statistical analysis was performed with nonparametric Wilcoxon signed-rank test for comparison of histological and radiological parameters between the two groups. Results. Histological findings revealed a significant increase in percentages of new bone in the Ostim group (). Furthermore, new bone density was greater with Ostim compared to Bio-Oss (); however, the difference in height increase after surgery did not reach statistical significance (). Conclusion. Despite the limitations of this trial, Ostim and Bio-Oss are useful biomaterials in sinus augmentation and Ostim seems to be even more effective in new bone formation.