Table of Contents
International Scholarly Research Notices
Volume 2015, Article ID 170236, 16 pages
Research Article

Examining Provincial HPV Vaccination Schemes in Canada: Should We Standardise the Grade of Vaccination or the Number of Doses?

1Department of Mathematics, The University of Ottawa, 585 King Edward Avenue, Ottawa, ON, Canada K1N 6N5
2Department of Mathematics and Faculty of Medicine, The University of Ottawa, 585 King Edward Avenue, Ottawa, ON, Canada K1N 6N5

Received 5 November 2014; Accepted 19 March 2015

Academic Editor: San-Lin You

Copyright © 2015 Carley Rogers and Robert J. Smith?. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Human papillomavirus (HPV) infection is the most common sexually transmitted infection, which is linked to several cancers and genital warts. Depending on the Canadian province, the quadrivalent vaccine is given to girls in grades 4 through 10 with either a two- or three-dose schedule. We use a mathematical model to address the following research questions: (1) Does the grade at which the girls are vaccinated significantly affect the outcome of the program? (2) What coverage rate must the provinces reach in order to reduce the impact of HPV on the Canadian population? (3) What are the implications of vaccinating with two versus three doses? The model suggests the grade of vaccination and the number of doses do not make a significant difference to the outcome of the public vaccination program. The most significant factor is the coverage rate of children and adults. We recommend that provinces vaccinate as early as possible to avoid vaccine failure due to previous infection. We also recommend that the main focus of the program should be on obtaining a large enough coverage rate for children and/or adults in order to achieve the desired outcome with either two or three doses of the vaccine.