Novel Starch-PVA Polymer for Microparticle Preparation and Optimization Using Factorial Design Study

Table 2

The factorial design layout for nine formulations F1 to F9.

(a)

Batch code	Variable levels in coded forms^b					Percent drug load^d
						%
F7	−1	−1	33.11	47.89	56.09	34.63
F8	−1	0	28.88	56.12	63.97	31.19
F9	−1	1	26.99	41.02	48.57	41.21
F4	0	−1	31.58	58.99	74.11	39.11
F5	0	0	31.99	70.98	85.97	33.97
F6	0	1	34.75	61.09	75.29	33.09
F1	1	−1	13.91	24.27	34.11	39.45
F2	1	0	18.94	39.00	50.57	43.43
F3	1	1	26.34	28.97	43.98	41.33

indicated the amount of starch and the amount of PVA in mg.
^c denoted cumulative drug release at th minutes.
^dEvaluated on the basis of mass of Ornidazole used at the time of preparation and the mass of Ornidazole found entrapped in each formulation.

(b)

Coded values	Actual values
	−1	1.0	0.5
0	1.2	0.8
1	1.5	1.0