Toxicity Evaluation of Pũrṇa Cantirotaya Centũram, a Siddha Medicine in Wistar Rats
Table 1
Effect of Pũrṇa Cantirotaya Centũram on hematological parameters.
Parameters
Control (honey)
Low dose (2.5 mg/kg b.w.)
Mid dose (25 mg/kg b.w.)
High dose (50 mg/kg b.w.)
WBC (109/L)
8.06 ± 5.06
5.26 ± 4.11
6.87 ± 4.68
7.48 ± 6.19
Lymph %
62.13 ± 11.72
61.89 ± 20.71
56.05 ± 7.99
60.22 ± 5.43
Mon %
4.30 ± 1.79
3.42 ± 1.38
3.66 ± 0.35
4.46 ± 1.52
Gran %
34.32 ± 9.79
34.69 ± 19.48
40.29 ± 7.99
35.32 ± 3.97
RBC (1012/L)
7.16 ± 3.58
5.29 ± 3.57
6.70 ± 3.06
7.76 ± 3.66
HGB (g/dL)
12.11 ± 6.03
8.90 ± 6.09
11.27 ± 5.77
12.45 ± 5.84
HCT %
35.02 ± 18.06
26.36 ± 18.17
31.00 ± 14.24
37.33 ± 17.54
MCV (fL)
51.66 ± 5.99
49.97 ± 3.42
48.52 ± 2.69
49.07 ± 1.64
MCH (pg)
17.82 ± 2.90
16.68 ± 1.26
16.38 ± 1.05
16.27 ± 0.58
MCHC (g/dL)
34.67 ± 2.63
33.55 ± 1.57
30.57 ± 10.74
33.27 ± 0.57
RDW %
13.05 ± 3.81
11.44 ± 0.89
11.650 ± 1.23
11.43 ± 0.94
PLT (109/L)
200.70 ± 78.19
210.9 ± 55.6
227.5 ± 55.95
196.50 ± 144.17
MPV (fL)
6.53 ± 0.62
6.76 ± 1.03
6.38 ± 0.76
6.50 ± 0.64
PDW
15.30 ± 0.47
15.74 ± 0.89
15.45 ± 0.55
15.130 ± 0.46
PCT %
0.131 ± 0.04
0.130 ± 0.03
0.142 ± 0.035
0.130 ± 0.10
Comparison was made between vehicle control and test groups using the one-way ANOVA test followed by Dunnett’s test. Values are mean ± SD for 10 rats in each group ( ≤ 0.05). RBC: red blood corpuscles; HGB: hemoglobin; HCT: hematocrit; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; WBC: white blood cells; PLT: platelets; MPV: mean platelet volume; PCT: plateletcrit; RDW: red blood cell distribution width; PDW: platelet distribution width.
