Toxicity Evaluation of Pũrṇa Cantirotaya Centũram, a Siddha Medicine in Wistar Rats
Table 2
Effect of Pũrṇa Cantirotaya Centũram on biochemistry parameters.
Parameters
Control (honey)
Low dose (2.5 mg/kg b.w.)
Mid dose (25 mg/kg b.w.)
High dose (50 mg/kg b.w.)
Glucose (mg/dL)
111.20 ± 21.07
90.20 ± 27.93
94.20 ± 29.65
102.10 ± 38.30
Blood urea (mg/dL)
34.90 ± 8.97
46.60 ± 9.1
39.90 ± 8.99
29.80 ± 6.4
Creatinine (mg%)
0.73 ± 0.24
0.990 ± 0.3
0.92 ± 0.36
0.62 ± 0.12
Cholesterol (mg/dL)
112.70 ± 38.86
153.30 ± 45.3
110.70 ± 42.06
94.80 ± 17.88
TGL (mg/dL)
89.00 ± 18.08
87.10 ± 29.77
75.80 ± 19.11
87.40 ± 25.20
Total protein (g%)
8.32 ± 0.56
8.38 ± 0.64
10.24 ± 2.17
10.15 ± 3.67
Albumin (g%)
2.79 ± 0.35
3.04 ± 0.4
2.35 ± 0.45
2.98 ± 0.43
S. bilirubin (mg/dL)
0.710 ± 0.119
0.74 ± 0.06
0.630 ± 0.14
0.610 ± 0.21
SGOT (IU/L)
168.00 ± 14.81
165.50 ± 19.092
167.80 ± 16.19
169.10 ± 12.76
SGPT (IU/L)
62.00 ± 8.91
57.70 ± 14.855
49.40 ± 8.05
67.60 ± 41.21
(mEq/L)
130.10 ± 5.56
132.20 ± 2.300
133.10 ± 1.66
133.10 ± 2.02
(mEq/L)
5.76 ± 2.43
6.26 ± 1.1909
5.590 ± 1.20
5.240 ± 0.72
(mEq/L)
107.00 ± 1.41
106.30 ± 1.947
105.90 ± 1.79
105.90 ± 1.79
Comparison was made between vehicle control and test groups using the one-way ANOVA test followed by Dunnett’s test. Values are mean ± SD for 10 rats in each group ( < 0.05). TGL: triglycerides, SGOT: serum glutamic oxaloacetic transaminase, SGPT: serum glutamic pyruvic transaminase, : sodium, : potassium, and : chloride.
