Toxicity Evaluation of Pũrṇa Cantirotaya Centũram, a Siddha Medicine in Wistar Rats
Table 3
Effect of Pũrṇa Cantirotaya Centũram on relative organ weight (in grams).
Organs
Control (honey)
Low dose (2.5 mg/kg b.w.)
Mid dose (25 mg/kg b.w.)
High dose (50 mg/kg b.w.)
Brain
0.938 ± 0.136
1.028 ± 0.212
0.939 ± 0.105
0.865 ± 0.178
Heart
0.411 ± 0.062
0.419 ± 0.116
0.404 ± 0.113
0.436 ± 0.098
Lung
0.917 ± 0.473
0.882 ± 0.347
1.027 ± 0.604
0.69 ± 0.103
Liver
3.875 ± 0.560
4.107 ± 0.814
3.799 ± 0.863
3.986 ± 1.33
Stomach
0.507 ± 0.095
0.530 ± 0.101
0.539 ± 0.133
0.527 ± 0.130
Spleen
0.9 ± 0.114
0.833 ± 0.190
0.816 ± 0.104
0.975 ± 0.536
Thymus
0.402 ± 0.084
0.392 ± 0.131
0.381 ± 0.087
0.386 ± 0.072
Kidney right
0.151 ± 0.034
0.185 ± 0.049
0.15 ± 0.059
0.149 ± 0.023
Kidney left
0.528 ± 0.103
0.55 ± 0.099
0.547 ± 0.134
0.523 ± 0.150
Testis
1.39 ± 0.219
1.67 ± 0.376
1.55 ± 0.112
1.49 ± 0.258
Ovary
0.072 ± 0.019
0.057 ± 0.026
0.058 ± 0.023
0.075 ± 0.023
Comparison was made between vehicle control and test groups using the one-way ANOVA test followed by Dunnett’s test. Values are mean ± SD for 10 rats in each group ( < 0.05).