Table of Contents
International Scholarly Research Notices
Volume 2015 (2015), Article ID 480418, 6 pages
http://dx.doi.org/10.1155/2015/480418
Research Article

Association between Serum Bilirubin and Estimated Glomerular Filtration Rate among Diabetic Patients

1Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan
2Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan

Received 27 October 2014; Revised 19 December 2014; Accepted 2 January 2015

Academic Editor: Hamadi Fetoui

Copyright © 2015 Takeaki Katoh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The subjects comprised 230 men aged 77 ± 10 (range: 50–100) years and 279 women aged 81 ± 10 (50–101) years that visited the medical department. We examined the relationship between increased serum bilirubin and renal function evaluated by estimated glomerular filtration rate (eGFR) using CKD-EPI equations modified by a Japanese coefficient. Compared with the fourth quartile in serum bilirubin (1.01–1.97 mg/dL), the nonadjusted, age and gender-adjusted, and multivariate-adjusted odds ratios 95% confidence interval (CI) of eGFR <60 mL/min/1.73 m2 for the first quartile in serum bilirubin (0.13–0.50 mg/dL) were 2.08 (1.25–3.44), 1.82 (1.07–3.09), and 1.53 (0.83–2.81), respectively. Moreover, compared with the fourth quartile, nonadjusted, age and gender-adjusted, and multivariate-adjusted odds ratios (95% CI) of eGFR <45 mL/min/1.73 m2 for the first quartile were 3.50 (1.95–6.23), 3.12 (1.72–5.65), and 3.53 (1.71–7.26), respectively. The data were further stratified by gender, age, medication (antihypertensive, antidyslipidemic, and antidiabetic agents), and prevalence of cardiovascular disease (CVD). The standardized coefficients for eGFR were significant in all the subgroups other than the prevalence of CVD, and there were significant interactions between the two groups regarding CVD. Our data demonstrated an independent positive association between serum bilirubin and eGFR among diabetic patients.