Nephrogenic Adenoma of the Urinary Bladder: A Review of the Literature

Figure 4

(a) Nephrogenic adenoma (NA) involving prostate urethra. Note tubules and cysts lined by hobnail cells with a hyaline sheath surrounding some of the tubules, inflamed stroma, adjacent urothelium, and no significant cytologic atypia. (b) Nephrogenic adenoma involving prostatic urethra showing nuclear positivity with PAX2; (c through f) nested variant of urothelial carcinoma, (c) irregular proliferation of discrete nests with bland cytology separated by oedematous stroma. (d) Frequent tubular differentiation is noted. (e) Despite overall bland cytology, cells with random cytologic atypia can be seen (arrows). (f) Nested variant of urothelial carcinoma invading into muscularis propria and showing focal high-grade cytologic atypia (arrows). (g) Clear cell adenocarcinoma with prominent tubular architecture mimicking NA. (h) Clear cell adenocarcinoma with solid growth pattern and obvious nuclear atypia (haematoxylin-eosin, original magnification ×200 (a through f and h) and ×100 (g)). The figure was reprinted from Kunju Nephrogenic adenoma of report of a case and review of morphologic mimics. Archives of Pathology and Laboratory Medicine 2010; 134: 1455–1459 with permission from Archives of Pathology and Laboratory Medicine copyright 2008, College of American Pathologists. This permission is exclusive to this request specifically for this paper. Additional usage of any printed or electronic material for which the Archives of Pathology and Laboratory Medicine owns copyright would require permission from the editorial office.

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