Research Article

High Risk Stage 2 and Stage 3 Colon Cancer, Predictors of Recurrence and Effect of Adjuvant Therapy in a Nonselected Population

Table 2

Effect of adjuvant therapy on (recurrence-free) survival.

Stage 2 − adj TxStage 2 + adj TxStage 3 − adj TxStage 3 + adj Tx

Number of patients13993857
Recurrence rate0,190,330,3790,420,41,000
Median OS (iqr)6,42 (4,25–8,59)6,17 (2,08–7,42)0,7721,79 (0,60–6,07)5,51 (4,06–7,47)0,000
Median RFS (iqr)5,73 (2.76–8,11)5,49 (1.33–7,31)0,3251,19 (0,36–5,94)5,08 (2,12–7,40)0,084
Median age (iqr)75,3 (65,4–80,4)61,0 (59,3–65,7)0,00278,7 (73,9–83,1)63,5 (59,8–69,8)0,000
Median Charlson index (iqr)5 (3–6)3 (2–4.5)0,0385 (4–6)3 (3-4)0,000
Cause of death (%)
 Alive87 (56)5 (56)8 (21)32 (56)
 Cancer18 (13)3 (33)15 (40)18 (32)
 Treatment3 (2)1 (11)8 (21)0
 Other29 (21)06 (16)5 (9)
 Unknown11 (8)01 (3)2 (4)

Adj Tx = adjuvant therapy; iqr = interquartile range; OS = overall survival; RFS = recurrence-free survival.