Research Article
Use of Genotype MTBDRplus Assay for Diagnosis of Multidrug-Resistant Tuberculosis in Nepal
Table 1
Patterns of amino acid changes and mutations in rpoB gene.
| | Number of isolates (%) | Amino acid changes in rpoB gene | MTBDRplus assay RIF mutation patterns (rpoB gene) | Finding |
| | 14 (20.3%) | No change | WT | | | 2 (2.9%) | Not known | Δ WT8 | | | 44 (63.8%) | rpoBS531L (Ser-Leu) | Δ WT8, MUT3 | | | 3 (4.3%) | Not known | ΔWT7 | | | 2 (2.9%) | rpoBH526Y (His-Tyr) | ΔWT7, MUT2A | | | 1 (1.4%) | Not known | ΔWT5, 6 | | | 3 (4.3%) | rpoBD516V (Asp-Val) | Δ WT3,4, MUT1 | |
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