Table of Contents
International Scholarly Research Notices
Volume 2017 (2017), Article ID 2624947, 7 pages
https://doi.org/10.1155/2017/2624947
Research Article

Formulation and Development of a Validated UV-Spectrophotometric Analytical Method of Rutin Tablet

1Department of Pharmacy, Faculty of Medicine & Health Sciences, An-Najah National University, P.O. Box 7, Nablus, State of Palestine
2Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK

Correspondence should be addressed to Murad N. Abualhasan

Received 4 February 2017; Revised 20 March 2017; Accepted 29 March 2017; Published 16 May 2017

Academic Editor: Josep Esteve-Romero

Copyright © 2017 Murad N. Abualhasan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Rutin is available in some foods, fruits, and vegetables. It has various beneficial medical effects making it useful in the treatment of various diseases. Rutin is available in different oral dosage forms such as tablets or capsules, widely available in the market. Rutin and many herbal medicines lack quality control due to unavailability of analytical methods. In this study, we formulated rutin tablet and studied its stability using a simple developed analytical method. The dissolution profile of our formulated tablet was also inspected. The results showed that our developed method was linear (), precise (% RSD = 0.026), and accurate (% recovery = 98.55–103.34). The formulated rutin tablet was stable under accelerated conditions as well as room temperature for 150 days (% assay > 91.69). The dissolution profile over 45 minutes of our formulated tablet showed a better dissolution (26.5%) compared with the internationally marketed Rutin® tablet (18.5%). This study can serve as a guideline to companies that manufacture herbal products to improve their formulated herbs and apply validated analytical methods to check the quality of their product.