Table of Contents 
International Scholarly Research Notices
Volume 2017, Article ID 6875195, 4 pages
https://doi.org/10.1155/2017/6875195
Research Article

S-100β and Antioxidant Capacity in Cerebrospinal Fluid during and after Thoracic Endovascular Aortic Repair

Koichiro Nandate, Deepak Sharma, Hernando Olivar, Matthew Hallman, Ramesh Ramaiah, Aaron Joffe, Anthony Roche, and Vijay Krishnamoorthy

Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA

Correspondence should be addressed to Vijay Krishnamoorthy; ude.notgnihsaw.u@hsirkv

Received 14 February 2017; Revised 10 May 2017; Accepted 31 May 2017; Published 27 June 2017

Academic Editor: Suhel Parvez

Copyright © 2017 Koichiro Nandate et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Thoracic Endovascular Aortic Repair (TEVAR) has substantially decreased the mortality and major complications from aortic surgery. However, neurological complications such as spinal cord ischemia may still occur after TEVAR. S-100β is a biomarker of central nervous system injury, and oxidant injury plays an important role in neurological injury. In this pilot study, we examined the trends of S-100β and antioxidant capacity in the CSF during and after TEVAR. Methods. We recruited 10 patients who underwent elective TEVAR. CSF samples were collected through a lumbar catheter at the following time points: before the start of surgery () and immediately () and 24 () and 48 hours () after the deployment of the aortic stent. S-100β and CSF antioxidant capacity were analyzed with the use of commercially available kits. Results. We observed that the level of S-100β in all of the subjects at 24 hours after the deployment of the aortic stent () increased. However, the levels of S-100β at and were comparable to the baseline value. The antioxidant capacity remained unchanged. No patient had a clinical neurologic complication. Conclusions. Our observations may indicate biochemical/subclinical central nervous system injury attributable to the deployment of the aortic stent.