Table of Contents
Journal of Allergy
Volume 2010, Article ID 251758, 9 pages
Research Article

Body Mass and Fat Mass in Refractory Asthma: An Observational 1 Year Follow-Up Study

Institute for Lung Health, Clinical Sciences Wing, University Hospitals of Leicester, Groby Road, Leicester LE3 9QP, UK

Received 7 July 2010; Revised 7 September 2010; Accepted 19 October 2010

Academic Editor: Stephen P. Peters

Copyright © 2010 Mona Bafadhel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Asthma and obesity are common; however the impact of obesity upon asthma remains uncertain. Objectives. To assess relationships between obesity and fat mass with airway inflammation, lung function, and disease control in patients with refractory asthma. Methods. 151 refractory asthma patients were characterised for measures of airway inflammation, lung function, Juniper asthma control questionnaire (JACQ), body mass index (BMI), and fat mass index (FMI) derived from dual energy X-ray absorptiometry. Patients were reassessed over 12 months. Results. 74% of patients had an elevated BMI. BMI and FMI correlated ( , ). FMI and JACQ correlated in men ( , ). After 12 months 23% lost weight. Weight change over 12 months correlated with FEV1 change ( , ), but not with change in JACQ or exacerbations. Conclusion. Increased fat mass is common in refractory asthma and is associated with asthma symptom control in men. Loss of weight is associated with improvement in lung function in refractory asthma.