Body Mass and Fat Mass in Refractory Asthma: An Observational 1 Year Follow-Up Study
Table 1
Patient demographics.
Women
Characteristics in women stratified into FMI tertiles
Men
Characteristics in men stratified into FMI tertiles
Value
Value
Number,
82
27
28
27
69
23
23
23
Age*
46 (19–79)
45 (20–74)
48 (23–79)
48 (19–67)
0.60
52 (18–80)
55 (23–78)
52 (23–80)
50 (18–78)
0.42
Age of onset of asthma*
20 (2–73)
20 (1–58)
21 (1–73)
21 (1–46)
0.99
28 (2–79)
24 (1–58)
31 (1–79)
30 (1–75)
0.53
Disease duration yrs
26 (2)
24 (3)
27 (3)
27 (3)
0.71
24 (2)
31 (4)
20 (4)
20 (3)
0.06
Never smokers %
85
82
89
85
0.71
84
78
96
78
0.18
Pack year history
4 (1)
6 (3)
3 (1)
3 (1)
0.39
6 (2)
6 (2)
3 (2)
9 (6)
0.39
Positive atopy status %
68
76
61
69
0.07
66
65
77
55
0.07
Exacerbation rate in previous yr
4.3 (0.4)
4.5 (0.6)
4.0 (0.6)
4.4 (0.8)
0.87
3.5 (0.4)
3.5 (0.7)
3.6 (0.7)
3.3 (0.7)
0.96
Maintenance prednisolone %
51
52
54
48
0.69
48
52
39
52
0.10
Prednisolone dose mg*
11 (5–40)
14 (5–40)
9 (5–15)
12 (5–23)
0.20
11 (5–20)
11 (5–20)
13 (5–20)
11 (5–20)
0.46
Inhaled corticosteroid %
100
100
100
100
1.00
100
100
100
100
1.00
Inhaled corticosteroid dose μg
1490 (89)
1427 (150)
1393 (117)
1652 (189)
0.44
1547 (86)
1530 (158)
1539 (130)
1648 (84)
0.83
Long-acting beta agonist %
90
83
93
92
0.62
93
91
91
96
0.90
Total IgE (kU/L)
504 (118)
835 (286)
309 (134)
374 (190)
0.14
644 (132)
638 (293)
770 (198)
523 (189)
0.75
FEV1 % predicted#
81 (2)
88 (4)
76 (4)
79 (4)
0.08
73 (3)
73 (4)
69 (5)
76 (5)
0.60
FEV1 / FVC# (%)
74 (1)
77 (2)
72 (2)
74 (2)
0.18
67 (2)
65 (3)
65 (3)
71 (2)
0.23
FENO ¶ (ppb)
32 (24–42)
32 (21–51)
30 (15–58)
33 (20–53)
0.99
34 (26–43)
26 (16–41)
37 (21–65)
41 (28–59)
0.39
Sputum eosinophil count¶ (%)
5 (3–7)
3 (1–9)
6 (3–14)
6 (3–11)
0.31
5 (3–7)
5 (3–9)
5 (2–11)
5 (2–10)
0.72
Sputum neutrophil count (%)
55 (3)
51 (6)
60 (5)
55 (5)
0.48
59 (3)
58 (6)
59 (5)
62 (5)
0.88
JACQ score
2.4 (0.1)
2.4 (0.3)
2.5 (0.2)
2.4 (0.3)
0.92
2.2 (0.2)
1.5 (0.2)
2.3 (0.3)
2.7 (0.2)
<0.001
JACQ score(independent of )
2.3 (0.2)
2.4 (0.3)
2.4 (0.2)
2.3 (0.3)
0.97
2.0 (0.2)
1.2 (0.2)
2.0 (0.3)
2.7 (0.2)
0.01
BMI (kg/m2)
30.0 (0.7)
23.2 (0.5)
30.1 (0.6)
36.7 (1.0)
<0.001
29 (1)
23.7 (0.6)
27.4 (0.6)
36.0 (1.1)
<0.001
FMI (kg/m2)
13.3 (0.6)
7.9 (0.4)
13.5 (0.4)
18.6 (0.7)
<0.001
10 (0.5)
6.1 (0.3)
8.9 (0.3)
14.2 (0.6)
<0.001
Data presented as mean (SEM) unless otherwise stated. *Mean [range]; BDP equivalent. FEV1: forced expiratory volume in 1 second, FVC: forced vital capacity, FENO: fraction of exhaled nitric oxide, JACQ: Juniper asthma control questionnaire score, BMI: body mass index, FMI: fat mass index. Data presented as mean (SEM) unless otherwise stated; #postbronchodilator; ¶geometric mean (95% CI).