Table of Contents
Journal of Allergy
Volume 2011 (2011), Article ID 346719, 7 pages
http://dx.doi.org/10.1155/2011/346719
Review Article

Genetic Variability in Susceptibility to Occupational Respiratory Sensitization

Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA

Received 22 February 2011; Accepted 18 April 2011

Academic Editor: Gordon L. Sussman

Copyright © 2011 Berran Yucesoy and Victor J. Johnson. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Maestrelli, P. Boschetto, L. M. Fabbri, and C. E. Mapp, “Mechanisms of occupational asthma,” Journal of Allergy and Clinical Immunology, vol. 123, no. 3, pp. 531–542, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. E. Meijer, D. E. Grobbee, and D. Heederik, “Detection of workers sensitised to high molecular weight allergens: a diagnostic study in laboratory animal workers,” Occupational and Environmental Medicine, vol. 59, no. 3, pp. 189–195, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Chan-Yeung, “Occupational asthma,” The New England Journal of Medicine, vol. 333, pp. 107–112, 1995. View at Google Scholar · View at Scopus
  4. S. N. Kelada, D. L. Eaton, S. S. Wang, N. R. Rothman, and M. J. Khoury, “The role of genetic polymorphisms in environmental health,” Environmental Health Perspectives, vol. 111, no. 8, pp. 1055–1064, 2003. View at Google Scholar · View at Scopus
  5. NIOSH, National Occupational Exposure Survey (NOES), 1981–1983, 1983.
  6. C. A. Redlich and M. H. Karol, “Diisocyanate asthma: clinical aspects and immunopathogenesis,” International Immunopharmacology, vol. 2, no. 2, pp. 213–224, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. J. A. Bernstein, “Overview of diisocyanate occupational asthma,” Toxicology, vol. 111, pp. 181–189, 1996. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Rydzynski and C. Palczynski, “Occupational allergy as a challenge to developing countries,” Toxicology, vol. 198, no. 1–3, pp. 75–82, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. D. I. Bernstein, L. Korbee, T. Stauder et al., “The low prevalence of occupational asthma and antibody-dependent sensitization to diphenylmethane diisocyanate in a plant engineered for minimal exposure to diisocyanates,” Journal of Allergy and Clinical Immunology, vol. 92, no. 3, pp. 387–396, 1993. View at Google Scholar · View at Scopus
  10. M. L. Wang and E. L. Petsonk, “Symptom onset in the first 2 years of employment at a wood products plant using diisocyanates: some observations relevant to occupational medical screening,” American Journal of Industrial Medicine, vol. 46, no. 3, pp. 226–233, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. S. M. Tarlo, D. Banks, G. Liss, and I. Broder, “Outcome determinants for isocyanate induced occupational asthma among compensation claimants,” Occupational and Environmental Medicine, vol. 54, no. 10, pp. 756–761, 1997. View at Google Scholar · View at Scopus
  12. H. G. Ortega, D. N. Weissman, D. L. Carter, and D. Banks, “Use of specific inhalation challenge in the evaluation of workers at risk for occupational asthma: a survey of pulmonary, allergy, and occupational medicine residency training programs in the United States and Canada,” Chest, vol. 121, no. 4, pp. 1323–1328, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. A. J. Frew, “What can we learn about asthma from studying occupational asthma?” Annals of Allergy, Asthma and Immunology, vol. 90, no. 5, pp. 7–10, 2003. View at Google Scholar · View at Scopus
  14. Y. Zhang, N. I. Leaves, G. G. Anderson et al., “Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma,” Nature Genetics, vol. 34, no. 2, pp. 181–186, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. M. Allen, A. Heinzmann, E. Noguchi et al., “Positional cloning of a novel gene influencing asthma from Chromosome 2q14,” Nature Genetics, vol. 35, no. 3, pp. 258–263, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. P. Van Eerdewegh, R. D. Little, J. Dupuis et al., “Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness,” Nature, vol. 418, no. 6896, pp. 426–430, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. T. Laitinen, A. Polvi, P. Rydman et al., “Characterization of a common susceptibility locus for asthma-related traits,” Science, vol. 304, no. 5668, pp. 300–304, 2004. View at Publisher · View at Google Scholar · View at PubMed
  18. C. E. Mapp, A. A. Fryer, N. D. Marzo et al., “Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by isocyanates,” Journal of Allergy and Clinical Immunology, vol. 109, no. 5, pp. 867–872, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. C. E. Mapp, B. Beghè, A. Balboni et al., “Association between HLA genes and susceptibility to toluene diisocyanate-induced asthma,” Clinical and Experimental Allergy, vol. 30, no. 5, pp. 651–656, 2000. View at Publisher · View at Google Scholar · View at Scopus
  20. Z. Wang, C. Chen, T. Niu et al., “Association of asthma with β-adrenergic receptor gene polymorphism and cigarette smoking,” American Journal of Respiratory and Critical Care Medicine, vol. 163, no. 6, pp. 1404–1409, 2001. View at Google Scholar · View at Scopus
  21. C. Brasch-Andersen, Q. Tan, A. D. Børglum et al., “Significant linkage to chromosome 12q24.32-q24.33 and identification of SFRS8 as a possible asthma susceptibility gene,” Thorax, vol. 61, no. 10, pp. 874–879, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. C. Ober and S. Hoffjan, “Asthma genetics 2006: the long and winding road to gene discovery,” Genes and Immunity, vol. 7, no. 2, pp. 95–100, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. C. E. Mapp, “The role of genetic factors in occupational asthma,” European Respiratory Journal, vol. 22, no. 1, pp. 173–178, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. A. M. Bentley, P. Maestrelli, M. Saetta et al., “Activated T-lymphocytes and eosinophils in the bronchial mucosa in isocyanate-induced asthma,” Journal of Allergy and Clinical Immunology, vol. 89, no. 4, pp. 821–829, 1992. View at Google Scholar · View at Scopus
  25. H. S. Park, H. Y. Kim, D. H. Nahm, J. W. Son, and Y. Y. Kim, “Specific IgG, but not specific IgE, antibodies to toluene diisocyanate-human serum albumin conjugate are associated with toluene diisocyanate bronchoprovocation test results,” Journal of Allergy and Clinical Immunology, vol. 104, no. 4 I, pp. 847–851, 1999. View at Google Scholar · View at Scopus
  26. J. L. Malo and M. Chan-Yeung, “Occupational asthma,” Journal of Allergy and Clinical Immunology, vol. 108, no. 3, pp. 317–328, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. J. S. Bignon, Y. Aron, . Li Ya Ju et al., “HLA Class II alleles in isocyanate-induced asthma,” American Journal of Respiratory and Critical Care Medicine, vol. 149, no. 1, pp. 71–75, 1994. View at Google Scholar · View at Scopus
  28. A. Balboni, O. P. Baricordi, L. M. Fabbri, E. Gandini, A. Ciaccia, and C. E. Mapp, “Association between toluene diisocyanate-induced asthma and DQB1 markers: a possible role for aspartic acid at position 57,” European Respiratory Journal, vol. 9, no. 2, pp. 207–210, 1996. View at Publisher · View at Google Scholar · View at Scopus
  29. S. H. Kim, H. B. Oh, K. W. Lee et al., “HLA DRB1*15-DPB1*05 haplotype: a susceptible gene marker for isocyanate-induced occupational asthma?” Allergy, vol. 61, no. 7, pp. 891–894, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. J. H. Choi, K. W. Lee, C. W. Kim et al., “The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype is a risk factor for toluene diisocyanate-induced occupational asthma,” International Archives of Allergy and Immunology, vol. 150, no. 2, pp. 156–163, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. D. I. Bernstein, N. Wang, P. Campo et al., “Diisocyanate asthma and gene-environment interactions with IL4RA, CD-14 and IL-13 genes,” Annals of Allergy, Asthma and Immunology, vol. 97, no. 6, pp. 800–806, 2006. View at Google Scholar · View at Scopus
  32. A. V. Wisnewski, Q. Liu, J. Liu, and C. A. Redlich, “Glutathione protects human airway proteins and epithelial cells from isocyanates,” Clinical and Experimental Allergy, vol. 35, no. 3, pp. 352–357, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. R. C. Lantz, R. Lemus, R. W. Lange, and M. H. Karol, “Rapid reduction of intracellular glutathione in human bronchial epithelial cells exposed to occupational levels of Toluene diisocyanate,” Toxicological Sciences, vol. 60, no. 2, pp. 348–355, 2001. View at Publisher · View at Google Scholar · View at Scopus
  34. P. Piirilä, H. Wikman, R. Luukkonen et al., “Glutathione S-transferase genotypes and allergic responses to diisocyanate exposure,” Pharmacogenetics, vol. 11, no. 5, pp. 437–445, 2001. View at Publisher · View at Google Scholar · View at Scopus
  35. H. Wikman, P. Piirilä, C. Rosenberg et al., “N-acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk,” Pharmacogenetics, vol. 12, no. 3, pp. 227–233, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. K. E. Broberg, M. Warholm, H. Tinnerberg et al., “The GSTP1 Ile105 Val polymorphism modifies the metabolism of toluene di-isocyanate,” Pharmacogenetics and Genomics, vol. 20, no. 2, pp. 104–111, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  37. Y. M. Ye, Y. M. Kang, S. H. Kim et al., “Relationship between neurokinin 2 receptor gene polymorphisms and serum vascular endothelial growth factor levels in patients with toluene diisocyanate-induced asthma,” Clinical and Experimental Allergy, vol. 36, no. 9, pp. 1153–1160, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  38. Y. M. Ye, Y. M. Kang, S. H. Kim et al., “Probable role of beta 2-adrenergic receptor gene haplotype in toluene diisocyanate-induced asthma,” Allergy, Asthma and Immunology Research, vol. 2, no. 4, pp. 260–266, 2010. View at Publisher · View at Google Scholar · View at PubMed
  39. S. H. Kim, B. Y. Cho, C. S. Park et al., “Alpha-T-catenin (CTNNA3) gene was identified as a risk variant for toluene diisocyanate-induced asthma by genome-wide association analysis,” Clinical and Experimental Allergy, vol. 39, no. 2, pp. 203–212, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  40. P. K. Henneberger, S. K. Goe, W. E. Miller, B. Doney, and D. W. Groce, “Industries in the United States with airborne beryllium exposure and estimates of the number of current workers potentially exposed,” Journal of Occupational and Environmental Hygiene, vol. 1, no. 10, pp. 648–659, 2004. View at Publisher · View at Google Scholar · View at Scopus
  41. L. A. Maier, D. S. McGrath, H. Sato et al., “Influence of MHC CLASS II in susceptibility to beryllium sensitization and chronic beryllium disease,” Journal of Immunology, vol. 171, no. 12, pp. 6910–6918, 2003. View at Google Scholar · View at Scopus
  42. L. S. Newman, M. M. Mroz, R. Balkissoon, and L. A. Maier, “Beryllium sensitization progresses to chronic beryllium disease: a longitudinal study of disease risk,” American Journal of Respiratory and Critical Care Medicine, vol. 171, no. 1, pp. 54–60, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  43. K. Kreiss, S. Wasserman, M. M. Mroz, and L. S. Newman, “Beryllium disease screening in the ceramics industry: blood lymphocyte test performance and exposure-disease relations,” Journal of Occupational Medicine, vol. 35, no. 3, pp. 267–274, 1993. View at Google Scholar · View at Scopus
  44. L. S. Newman, “Significance of the blood beryllium lymphocyte proliferation test,” Environmental Health Perspectives, vol. 104, no. 5, pp. 953–956, 1996. View at Google Scholar · View at Scopus
  45. K. Kreiss, M. M. Mroz, B. Zhen, J. W. Martyny, and L. S. Newman, “Epidemiology of beryllium sensitization and disease in nuclear workers,” American Review of Respiratory Disease, vol. 148, no. 4, pp. 985–991, 1993. View at Google Scholar · View at Scopus
  46. M. M. Mroz, K. Kreiss, D. C. Lezotte, P. A. Campbell, and L. S. Newman, “Reexamination of the blood lymphocyte transformation test in the diagnosis of chronic beryllium disease,” Journal of Allergy and Clinical Immunology, vol. 88, no. 1, pp. 54–60, 1991. View at Google Scholar · View at Scopus
  47. K. Kreiss, F. Miller, L. S. Newman, E. A. Ojo-Amaize, M. D. Rossman, and C. Saltini, “Chronic beryllium disease—from the workplace to cellular immunology, molecular immunogenetics, and back,” Clinical Immunology and Immunopathology, vol. 71, no. 2, pp. 123–129, 1994. View at Publisher · View at Google Scholar · View at Scopus
  48. K. Kreiss, G. A. Day, and C. R. Schuler, “Beryllium: a modern industrial hazard,” Annual Review of Public Health, vol. 28, pp. 259–277, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  49. D. Middleton and P. Kowalski, “Advances in identifying beryllium sensitization and disease,” International Journal of Environmental Research and Public Health, vol. 7, no. 1, pp. 115–124, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  50. E. C. McCanlies, J. S. Ensey, C. R. Schuler, K. Kreiss, and A. Weston, “The association between HLA-DPB1 and chronic beryllium disease and beryllium sensitization,” American Journal of Industrial Medicine, vol. 46, no. 2, pp. 95–103, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  51. L. Richeldi, R. Sorrentino, and C. Saltini, “HLA-DPB1 glutamate 69: a genetic marker of beryllium disease,” Science, vol. 262, no. 5131, pp. 242–244, 1993. View at Google Scholar · View at Scopus
  52. Z. Wang, G. M. Farris, L. S. Newman et al., “Beryllium sensitivity is linked to HLA-DP genotype,” Toxicology, vol. 165, no. 1, pp. 27–38, 2001. View at Publisher · View at Google Scholar · View at Scopus
  53. A. P. Fontenot, M. Torres, W. H. Marshall, L. S. Newman, and B. L. Kotzin, “Beryllium presentation to CD4+ T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 23, pp. 12717–12722, 2000. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  54. G. Lombardi, C. Germain, J. Uren et al., “HLA-DP allele-specific T cell responses to beryllium account for DP-associated susceptibility to chronic beryllium disease,” Journal of Immunology, vol. 166, no. 5, pp. 3549–3555, 2001. View at Google Scholar · View at Scopus
  55. M. D. Rossman, J. Stubbs, W. H. A. Chung Lee, E. Argyris, E. Magira, and D. Monos, “Human leukocyte antigen Class II amino acid epitopes: susceptibility and progression markers for beryllium hypersensitivity,” American Journal of Respiratory and Critical Care Medicine, vol. 165, no. 6, pp. 788–794, 2002. View at Google Scholar · View at Scopus
  56. Z. Wang, P. S. White, M. Petrovic et al., “Differential susceptibilities to chronic beryllium disease contributed by different Glu69 HLA-DPB1 and -DPA1 alleles,” Journal of Immunology, vol. 163, no. 3, pp. 1647–1653, 1999. View at Google Scholar · View at Scopus
  57. C. Saltini, L. Richeldi, M. Losi et al., “Major histocompatibility locus genetic markers of beryllium sensitization and disease,” European Respiratory Journal, vol. 18, no. 4, pp. 677–684, 2001. View at Publisher · View at Google Scholar · View at Scopus
  58. L. Richeldi, K. Kreiss, M. M. Mroz, B. Zhen, P. Tartoni, and C. Saltini, “Interaction of genetic and exposure factors in the prevalence of berylliosis,” American Journal of Industrial Medicine, vol. 32, no. 4, pp. 337–340, 1997. View at Publisher · View at Google Scholar · View at Scopus
  59. M. Amicosante, F. Berretta, M. Rossman et al., “Identification of HLA-DRPheβ47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGluβ69,” Respiratory Research, vol. 6, article 94, 2005. View at Publisher · View at Google Scholar · View at PubMed
  60. K. I. Gaede, M. Amicosante, M. Schürmann, E. Fireman, C. Saltini, and J. Müller-Quernheim, “Function associated transforming growth factor-β gene polymorphism in chronic beryllium disease,” Journal of Molecular Medicine, vol. 83, no. 5, pp. 397–405, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  61. K. D. Rosenman, M. Rossman, V. Hertzberg et al., “HLA class II DPB1 and DRB1 polymorphisms associated with genetic susceptibility to beryllium toxicity,” Occupational and Environmental Medicine. In press.
  62. G. Samuel and L. A. Maier, “Immunology of chronic beryllium disease,” Current Opinion in Allergy and Clinical Immunology, vol. 8, no. 2, pp. 126–134, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  63. M. V. Van Dyke, M. M. Mroz, and L. J. Silveira, “Exposure and genetics increase risk of beryllium sensitisation and chronic beryllium disease in the nuclear weapons industry,” Occupational and Environmental Medicine. In press.
  64. J. A. Snyder, E. Demchuk, E. C. McCanlies et al., “Impact of negatively charged patches on the surface of MHC class II antigen-presenting proteins on risk of chronic beryllium disease,” Journal of the Royal Society Interface, vol. 5, no. 24, pp. 749–758, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  65. H. Sato, L. Silveira, P. Spagnolo et al., “CC chemokine receptor 5 gene polymorphisms in beryllium disease,” European Respiratory Journal, vol. 36, no. 2, pp. 331–338, 2010. View at Publisher · View at Google Scholar · View at PubMed
  66. A. C. Jonth, L. Silveira, T. E. Fingerlin et al., “TGF-β 1 variants in chronic beryllium disease and sarcoidosis,” Journal of Immunology, vol. 179, no. 6, pp. 4255–4262, 2007. View at Google Scholar · View at Scopus
  67. L. M. Bekris, H. M. A. Viernes, F. M. Farin, L. A. Maier, T. J. Kavanagh, and T. K. Takaro, “Chronic beryllium disease and glutathione biosynthesis genes,” Journal of Occupational and Environmental Medicine, vol. 48, no. 6, pp. 599–606, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  68. E. C. McCanlies, C. R. Schuler, K. Kreiss, B. L. Frye, J. S. Ensey, and A. Weston, “TNF-α polymorphisms in chronic beryllium disease and beryllium sensitization,” Journal of Occupational and Environmental Medicine, vol. 49, no. 4, pp. 446–452, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  69. E. C. McCanlies, B. Yucesoy, A. Mnatsakanova et al., “Association between IL-1A single nucleotide polymorphisms and chronic beryllium disease and beryllium sensitization,” Journal of Occupational and Environmental Medicine, vol. 52, pp. 680–684, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  70. A. Weston, J. Ensey, K. Kreiss, C. Keshava, and E. McCanlies, “Racial differences in prevalence of a supratypic HLA-genetic marker immaterial to pre-employment testing for susceptibility to chronic beryllium disease,” American Journal of Industrial Medicine, vol. 41, no. 6, pp. 457–465, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus