Genetic Variability in Susceptibility to Occupational Respiratory Sensitization

Table 1

Examples of genetic associations for DA and CBD.

Disease	Gene	Variation	RR; 𝑃 value; OR (95% CI)	Reference
DA
	HLA-DQB1	*0503	RR=9.8, 𝑃<.04	[27]
	HLA-DQB1	*0501	RR=0.14, 𝑃<.03	[27]
	HLA-DQA1	*0104	𝑃=.008	[19]
	HLA-DRB1-DPB1	*15*05	𝑃=.001	[29]
	GSTM1	Null	1.89 (1.01–3.52)	[34]
	NAT1	Slow acetylator	7.77 (1.18–51.6)	[35]
	IL4RA, IL-13 R, CD14	I50V-R110Q-C159T	6.4 (1.57–26.12)	[31]
	CTNNA3	rs1786929	𝑃=.015	[39]
CBD
	HLA-DPB1	Glu69	9.4 (5.4–16.6)	[50]
	HLA-DQB1	G86	𝑃<.04	[55]
	HLA-DRB1	S11	𝑃<.03	[55]
	CCR5	-3458	𝑃<.0001	[65]
	TGFβ1	-509	𝑃=.01	[66]
	GCLC	TNR 7/7	0.28 (0.08–0.95)	[67]
	GCLM	-588 C/C	3.07 (1.00–9.37)	[67]
	IL-1A	-1142	3.02 (1.36–6.70)	[69]
		-3769	2.51 (1.21–5.19)	[69]
		-4697	2.56 (1.24–5.29)	[69]

RR: relative risk; OR: odds ratio.