|
| Penicillins |
|
| Reference | Year | Country | No. | Exposure | Latency | Respiratory symptoms | Skin test | Specific IgE | Bronchial provocation test | Oral challenge |
|
| [7] | 1953 | USA | 2 | penicillin | #1: “weeks”
#2: 1 year | #1: cough, rhinitis
#2: cough, rhinitis, wheeze | Procaine penicillin (+) | not reported | not reported | not reported |
| [8] | 1957 | France | 4 | penicillin | #1: “years”
#2: 3 months
#3: 1 year
#4: 1 year | #1: cough, rhinitis, dyspnoea
#2: dyspnoea, eczema
#3: dyspnoea
#4: asthma, dyspnoea, eczema | not reported | not reported | not reported | not reported |
| [9] | 1960 | France | 2 | penicillin | #1: 1 year
#2: 7 years | #1: asthma, urticaria
#2: asthma | #1: PMP* (+)
#2: penicillin (+) | not reported | not reported | not reported |
| [10] | 1974 | UK | 3 | ampicillin
BP*
6 APA* | #1: 2 years
#2: 2 years
#3: 2 years
| asthma ()
rhinitis ()
eczema ()
conjunctivitis () | ampicillin (−)
ampicillin polymer (−)
BPP* (−)
MDM* (−) | not reported | #1: ampicillin (+LR*)6APA* (+/−)
#2: ampicillin (+LR*)
BP*(+LR*)
commercial 6APA* (+LR*)
purified 6APA* (−)
BPP* (−)
#3: ampicillin (+LR*)
BP* (+LR*)
6APA* (−) | #1: ampicillin (−)
#2: ampicillin (+LR*) and intestinal symptoms
#3: BP* (+ER*) and urticaria |
| [11] | 1980 | Spain | 2 | amoxicillin
ampicillin | #1: 1 year
#2: 1 year
| #1: rhinitis, dyspnoea, wheeze
#2: cough, wheeze | not reported | negative | not reported | not reported |
| [12] | 1982 | Germany | 1 | ampicillin | NS* | cough, rhinitis, dyspnoea, fever | ampicillin (−) | BPP* (+) | antibiotic mix (+LR*) | not reported |
| [13] ne | 1997 | Belgium | 1 | amoxicillin | 6 months | cough, wheeze, rhinitis | not reported | not reported | amoxicillin (+ER* LR*) | not reported |
| [14] | 1998 | Spain | 1 | amoxicillin | 27 years | cough, rhinitis, wheeze, dyspnoea | amoxicillin (−)
ampicillin (−)
BP* (−)
BPP* (−)
MDM* (−)
| amoxicillin (+)
ampicillin (−)
(penicillin V (−) | amoxicillin: (+ER*)
penicillin V (−) | amoxicillin (+LR*)
penicillin V (−) |
|
| Cephalosporins |
|
| Reference | Year | Country | No. | Exposure | Latency | Allergic symptoms | Skin test | Specific IgE | Bronchial provocation test | Oral challenge |
|
| [11] | 1980 | Spain | 1 | cephalexin, | 3 months | cough, wheeze | PP* (−)
penicillin G (−) | negative | not reported | cephalosporin (NS) (+) and rhinitis, urticaria |
| [15] | 1981 | UK | 2 | 7ACA*
7CTD* | #1: NS*
#2: 10 years | #1: cough, rhinitis, chest tightness
#2: chest tightness, dyspnoea | #1: 7ACA (+)
7CTD (+)
cefalexin (−)
#2: cephalexin (+) | not reported | #1: 7ACA (+ER*)
7CTD (+ER*)
cephalexin (−)
#2: cephalexin (+ER*) | not reported |
| [16] | 1995 | UK | 1 | ceftazidime | 1 year | rhinitis, dyspnoea | not reported | not reported | ceftazidime (+ER* LR*) | not reported |
| [17] | 1996 | Italy | 1 | cefmetazole
7-ACA* | 1 year | cough, rhinitis, bronchospasm | cefmetazole (−)
7-ACA* (−) | penicillin G (−)
penicillin V (−) | cefmetazole (+NS*)
7-ACA (+NS*) | not reported |
| [18] | 1999 | Spain | 1 | cefadroxil | 9 months | cough, rhinitis, dyspnoea, chest tightness | PP* (−)
MDM* (−)
BP* (−)
amoxicillin (−)
cefadroxil (−) | penicillin G (−)
penicillin V (−)
amoxicillin (−)
ampicillin (−)
cefaclor (−) | cefadroxil (+ER*) | amoxicillin (−)
cephalexin (+ER*) |
| [19] | 2003 | Korea | 2 | cefteram | NS* | NS* | #1: cefteram (+)
#2: cefteram (+) | #1: cefteram-HSA* (+)
#2: cefteram-HSA* (+) | #1: cefteram (+ER*)
#2: cefteram (+ER*) | not reported |
| [20] | 2004 | Korea | 2 | 7-ACA*
ceftriaxone | 2 years | #1: rhinitis, respiratory symptoms
#2: rhinitis, respiratory symptoms | #1: 7-ACA* (+)
ceftriaxone (+)
#2: 7-ACA* (−)
ceftriaxone (−)
| #1: 7-ACA-HSA* (+)
#2: 7-ACA-HAS* (−) | #1: 7-ACA* (+ER*)
ceftriaxone (−)
#2: 7-ACA* (+NS*)
ceftriaxone (−) | not reported |
| [21] | 2009 | Italy | 1 | 7-TACA*
Cephalosporins | 8 months | cough, rhinitis, dyspnoea | not reported | not reported | 7-TACA*: (+ER*) | not reported |
|
| Miscellaneous |
|
| Reference | Year | Country | No. | Exposure | Latency | Allergic symptoms | Skin test | Specific IgE | Bronchial provocation test | Oral challenge |
|
| [22] | 1977 | India | 1 | tetracycline | 1 year | cough, wheeze, dyspnoea | not reported | not reported | tetracycline (+ER*) | tetracycline (+ER*) and urticaria |
| [23] | 1975 | UK | 1 | spiramycin | 1 year | cough, rhinitis, dyspnoea, dermatitis | spiramycin (+) | not reported | spiramycin (+LR*) | not reported |
| [24] | 1979 | Italy | 1 | spiramycin | 1 year | cough, asthma, dermatitis | spiramycin (+) | not reported | chick feed with spiramycin (+LR*) | not reported |
| [25] | 1984 | Italy | 2 | spiramycin
adipid acid | #1:14 years
#2:7 months | #1: dyspnoea
#2: cough, dyspnoea | not reported | not reported | #1: spiramycin adipate (+ER* LR*)
#2: spiramycin adipate (+ER*)
spiramycin base (+ER* LR*) | not reported |
| [26] | 1995 | Italy | 1 | piperacillin | 22 months | rhinitis, dyspnoea, wheeze, rash | piperacillin (+) | not reported | piperacillin (+ER*) | not reported |
| [27] | 2006 | Korea | 2 | thiamphenicol | NS* | #1: rhinitis, asthma
#2: rhinitis, asthma | #1: thiamphenicol (+)
#2: thiamphenicol (+) | #1: thiamphenicol (+)
#2 thiamphenicol (+) | #1: thiamphenicol (+ER*)
#2: thiamphenicol (+ER*) | not reported |
| [28] | 2009 | Korea | 1 | vancomycin | 5 months | rhinitis, chest tightness | vancomycin (−) | vancomycin-HSA* (−) | not reported | not reported |
| [29] | 2010 | Spain | 1 | colomycin | 3 months | rhinitis, cough, wheeze, dyspnoea | not reported | negative | colomycin (+ER*) | not reported |
|
