Effects of β Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts
Figure 2
(a–f) Effect of dexamethasone (Dex), fluticasone (Flut) and salmeterol (Sal) on RV-induced IL-6 and IL-8. Concentration of IL-6 and IL-8 release from noninfected fibroblasts (constitutive release), UVi-RV-(UVi-) or RV-16-infected fibroblasts (RV) (), highest concentration of vehicle (Dex & Sal: 0.1% DMSO; Flut: 0.001% DMSO) and RV infected fibroblasts in the presence of Dex: 10−12–10−7 M (), Flut: 10−10–10−8 M () and Sal: 10−8–10−6 M () were measured 48 hrs post infection by ELISA. All IL-6 and IL-8 concentrations were compared to their respective RV-induced values (in the absence of drug and vehicle), using a 1-way ANOVA. All data are presented as . Significance is represented as *, **, and ***.
