Effects of β𝟐 Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts

Figure 3

(a–d) Effect of BAY and DMF on RV-induced IL-6 and IL-8. Concentration of IL-6 and IL-8 release from noninfected fibroblast (constitutive release), UVi-RV-(UVi-) or RV-16-infected fibroblasts (RV) (MOI=0.1), highest concentration of vehicle (0.1% DMSO) and RV infected fibroblasts in the presence of 10⁻⁸–10⁻⁶ M BAY (𝑛=10) and DMF (𝑛=9) measured 48 hrs post infection by ELISA. All IL-6 and IL-8 concentrations were compared to their respective RV-induced values (in the absence of drug and vehicle), using a 1-way ANOVA. All data are presented as mean±SEM. Significance is represented as **𝑃<0.01 and ***𝑃<0.0001.

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