Effects of β𝟐 Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts

Figure 5

Salmeterol+fluticasone (Sal+Flut) and Sal+Flut+BAY inhibit RV-induced IL-6: the amount of IL-6 induced from fibroblasts infected with RV-16 (MOI=0.1) was expressed as 100%. Inhibition caused by drug combinations, Sal+Flut (10⁻⁸+10⁻¹⁰ M) and Sal+Flut+BAY (10⁻⁸+10⁻¹⁰+10⁻⁶ M) (for all 𝑛=4) was measured 48 hrs post infection by ELISA and expressed as a percentage of RV-induced IL-6. Percentage inhibition caused by drugs was compared using 1-way ANOVA with RV-induced IL-6. All data are presented as mean±SEM. Significance is represented as **𝑃<0.01.