Effects of β𝟐 Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts

Table 2

Effects of dexamethasone (Dex), fluticasone (Flut), and salmeterol (Sal) on the constitutive release of IL-6 and IL-8.

Constitutive release [pg/mL]				10^x [M]
Drug	Cytokine	Constitu-tive release	Vehicle	−12	−11	−10	−9	−8	−7	−6
Dex	IL-6	2874±1033	2974±1078	3295±1092	3734±1369	3387±913.8	2729±834.1	1576±567.4	1264±380.6
	IL-8	3305±1429	3424±1534	3277±1521	3376±1548	3499±1391	3206±1220	2590±1240	2492±1182
Flut	IL-6	6195±2429	6187±2400			1712±545.8^∗∗∗	1286±375.0^∗∗∗	1123±355.5^∗∗∗
	IL-8	8035±2609	8639±2977			3334±988.1^∗	2565±695.6^∗∗	2681±763.0^∗
Sal	IL-6	5646±2009	6620±2438					9440±4112^∗	7903±2955	6277±2335
	IL-8	4962±1698	5974±2023					8186±3583^∗∗	6122±2226^∗	5196±1807

Values are means±SEM.
* 𝑃<0.05, **𝑃<0.01, and ***𝑃<0.0001.