Inhalation of Ortho-Phthalaldehyde Vapor Causes Respiratory Sensitization in Mice
Figure 3
Inhalation of OPA vapor induces the expression of Th2, Th1, and pro/anti-inflammatory cytokines in the nasal mucosa of mice. Mice were exposed to OPA (125, 250, 500, 1000 ppb) or filtered air according to the schedule shown in Figure 1. Two days following the final exposure, the mucosal tissue lining the maxilloturbinates and lateral wall of the nasal cavity were removed and processed for gene expression analysis. Data are presented as mean () and represent fold change relative to the concurrent control group. *Indicates that the cytokine was significantly increased at one or more of the OPA concentrations. Refer to Table S1 for the empirical gene expression data.
