Clinical Study

A Randomised, Double-Blind Pilot Study of Enzyme-Potentiated Desensitisation for Prophylaxis of Large Local Reactions to Mosquito Bites

Table 2

Results for primary outcome measure, the mean square root of erythema area (SREA) at 1 hours and 24 hours post-bite.

OutcomeMean (SE) of SREA (mm) Mosquito antigen ( )Mean (SE) of SREA (mm) Placebo ( )Difference in mean SREA (drug-placebo)* (95% CI)

Baseline
 1 hour 31.3 (3.4) 24.5 (3.2)
 24 hours 33.7 (3.4) 28.7 (2.3)
Followup
 1 hour27.4 (2.9)22.6 (3.2)0.46 (−6.11 to 7.03)0.89
 24 hours35.1 (2.4)35.0 (2.9)−2.58 (−11.73 to 6.57)0.57
Proportion of participants with a decrease in SREA at
 1 hour14/24 (58%)12/25 (48%)
 24 hours8/24 (33%)9/25 (36%)

Adjusted for baseline values (ANCOVA analysis).