Interleukin-4 in the Generation of the AERD Phenotype: Implications for Molecular Mechanisms Driving Therapeutic Benefit of Aspirin Desensitization
Cytokine modulation of cysteinyl leukotriene receptor protein expression on T cells. T cells were separated from blood using magnetic bead affinity chromatography and stimulated with 20 ng/mL IL-4 for 16 hrs before cells were collected for analysis. Cell surface expression of the CysLTR1 receptor was evaluated using rabbit polyclonal anti-CysLTR1 followed by labeling with FITC-conjugated goat anti-rabbit IgG. Isotype control is shown in white, unstimulated in black, and IL-4 stimulated in gray. Reprinted with permission of the American Thoracic Society .
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