Neutrophil Inhibitory Factor Selectively Inhibits the Endothelium-Driven Transmigration of Eosinophils In Vitro and Airway Eosinophilia in OVA-Induced Allergic Lung Inflammation
Figure 1
Recombinant NIF inhibits lung eosinophil infiltration, and Th2 cytokine release. Immunized BALB/c mice were challenged intranasaly with either saline (NaCl), rNIF alone (NIF), OVA alone (OVA), or the combination OVA with 25 μg rNIF (OVA/NIF). Forty-eight hours after the third challenge, bronchoalveolar lavage (BAL) was performed and the cell composition determined. The total numbers of eosinophils (dotted bars), lymphocytes (black bars), macrophages (hatched bars), and neutrophils (white bars) are presented. Figure represents means ± SD of 6 animals per group (* indicates ).
