IgE-Mediated Anaphylaxis to Foods, Venom, and Drugs: Influence of Serum Angiotensin Converting Enzyme Levels and Genotype

Table 3

ACE genotype frequency for the groups and anaphylaxis grades.

ACE genotype	DD	ID	II	Healthy controls	Atopics	Anaphylaxis	Cutaneous and RS
Healthy controls (HC) 𝑁=119	53 (45%)	44 (37%)	22 (18%)		𝑃=0.14	𝑃=0.009	𝑃=0.053
Atopic controls 𝑁=49	15 (31%)	26 (53%)	8 (16%)	𝑃=0.14		𝑃=0.42	𝑃=0.025
Anaphylaxis 𝑁=120	30 (25%)	58 (50%)	32 (25%)	𝑃=0.009	𝑃=0.42
Cutaneous & respiratory anaphylaxis 𝑁=27	15 (56%)	12 (44%)	0 (0%)	𝑃=0.053	𝑃=0.025
Airway angioedema ± CVS collapse 𝑁=93	15 (16%)	46 (49%)	32 (35%)	𝑃<0.001	𝑃=0.024		𝑃<0.001
Traditional grades of anaphylaxis	DD	ID	II	Grade 1; 𝑃 value	Grade 2; 𝑃 value	Grade 3; 𝑃 value
Grade 1	4 (40%)	5 (50%)	1 (10%)		𝑃=0.12	𝑃=0.78
Grade 2	9 (17%)	25 (46%)	20 (37%)	𝑃=0.125		𝑃=0.048
Grade 3	16 (31%)	26 (51%)	9 (18%)	𝑃=0.783	𝑃=0.048
Grade 4	1 (20%)	2 (40%)	2 (40%)	𝑃=0.373	𝑃=0.96	𝑃=0.48