Clinical Study

Late Type of Bronchial Response to Milk Ingestion Challenge: A Comparison of Open and Double-Blind Challenge

Table 2

Survey of other diagnostic parameters.

PatientsControl subjects
TotalLARNAR

Bronchial complaints
 (i) Dyspnea++00
 (ii) Wheezing++00
 (iii) Cough ±00
 (iv) Expectoration000
Positive skin response (SPT)
 (i) Immediate31247
Negative skin response (SPT)2315811
Positive skin response (i.c.)◊◊372890
 (i) Immediate−15−12−3
 (ii) Late−21−15−6
 (iii) Delayed−1−1−0
Negative skin response (i.c.)17116
Increased total IgE (serum)□□1100
Positive specific IgE (serum)□□□9721
Increased total IgG (serum)2200
Increased sub-classes (serum)●●
 (i) IgG11100
 (ii) IgG20000
 (iii) IgG30000
 (iv) IgG42110
Increased total IgM (serum)●●●0000
Increased total IgA (serum)3300
Concomitant (allergic) disease
 (i) Allergic rhinitis8441
 (ii) Atopic eczema11920
 (iii) Urticaria1010
 (iv) Angio-neurotic edema0001
 (v) Gastrointestinal complaints5320

L: late asthmatic response; N: negative asthmatic response; : Bronchial complaints accompanying the asthmatic response (author’s modified score system): 0: absent, ±: very slight/incidental, +: slight, ++: moderate/intermittent, +++: pronounced/regularly, ++++: very pronounced/distinct/frequent; : skin prick test (SPT) with milk extract; ◊◊: intracutaneous (intradermal) skin test with milk extract; □□: total IgE in the serum (PRIST)-normal value ≤ 500 IU/mL; □□□: positive allergen-specific IgE in the serum for milk (ImmunoCAP) ≥ 0.70 U/mL (=more than class 1); : total IgGin the serum (Single radial immunodiffusion and ELISA)-normal value ≤ 15.0 g/L; ●●: normal values: IgG1 < 5.0 g/L,IgG2 < 2.6 g/L, IgG3 < 0.4 g/L, IgG4 < 0.5 g/L; ●●●: IgM ≤ 3.8 g/L (<1.5); : IgA ≤ 4.0 g/L (<3.2); : control subjects: 6 open (OFICH) + 6 double-blind (DBPCFC) food ingestion challenges with milk; : positive skin response to milk extract.