Airway Smooth Muscle Hypercontractility in Asthma

Figure 1

(a) Percentage contraction of collagen gels impregnated with airway smooth muscle from donors with asthma (𝑛=19) versus healthy control donors (𝑛=8) over 1 hour following stimulation with 1 nm bradykinin, (b) area under the curve gel contraction (mean [SEM]), and (c) representative gel photographs taken at 0 hour and 1 hour time points. The comparison was made by unpaired 𝑡-test. *𝑃<0.05. [17]. (Reprinted with permission of the American Thoracic Society. Copyright © 2012 American Thoracic Society. Amanda Sutcliffe, Fay Hollins, Edith Gomez, Ruth Saunders, Camille Doe, Marcus Cooke, R. A. John Challiss, and Chris E. Brightling/2012/ Increased Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Expression Mediates Intrinsic Airway Smooth Muscle Hypercontractility in Asthma. American Journal of Respiratory and Critical Care Medicine/Vol. 185/pp 267-274. (An official Journal of The American Thoracic Society).

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