Increased Expression of RhoA in Epithelium and Smooth Muscle of Obese Mouse Models: Implications for Isoprenoid Control of Airway Smooth Muscle and Fibroblasts
Figure 4
Inhibiting ROCK decreases ASM and NHLF proliferation. Inhibiting the Rho-associated kinase (ROCK), which mediates some of the downstream effects of RhoA, reduces (a) ASM (black bars) and (b) NHLF (grey bars) proliferation, assayed by MTS tetrazolium compound reduction (CellTiter). Data shown are the mean (±SE) of , run in 3 experiments (12 replicates each experiment); groups are compared by ANOVA with the Bonferroni test, .
