Increased Expression of RhoA in Epithelium and Smooth Muscle of Obese Mouse Models: Implications for Isoprenoid Control of Airway Smooth Muscle and Fibroblasts
Figure 5
Upregulating isoprenoid production increases ASM viability and proliferation. Increasing isoprenoid productionusing U18666a increases ASM proliferation as assayed by (a) MTS tetrazolium compound reduction (CellTiter, Promega) and (b) BrdU incorporation. Data shown are the mean (±SE) of , run in 3 experiments (12 replicates each experiment); groups are compared with ANOVA with the Bonferroni test, compared to no treatment (NT).
