Increased Expression of RhoA in Epithelium and Smooth Muscle of Obese Mouse Models: Implications for Isoprenoid Control of Airway Smooth Muscle and Fibroblasts

Figure 6

U18666a decreases NHLF viability. Increasing isoprenoid production and inhibiting cholesterol transport with U18666a inhibit the growth of normal human lung fibroblasts, assayed by (a) MTS tetrazolium compound reduction (CellTiter) and (b) BrdU incorporation. Data are shown as the mean (±SE) of 𝑛=36 run in 3 experiments (12 replicates each experiment); groups are compared by ANOVA with the Bonferroni test, ^∗𝑃<0.05.

(a)

(b)