Table of Contents
Journal of Allergy
Volume 2014, Article ID 146280, 8 pages
Clinical Study

Liposomal Nasal Spray versus Guideline-Recommended Steroid Nasal Spray in Patients with Chronic Rhinosinusitis: A Comparison of Tolerability and Quality of Life

1Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, 50924 Cologne, Germany
2Ear, Nose and Throat Department, General Hospital Hietzing, 1130 Vienna, Austria
3Center for Rhinology and Allergology, 65183 Wiesbaden, Germany

Received 19 February 2014; Revised 7 May 2014; Accepted 7 May 2014; Published 22 May 2014

Academic Editor: Desiderio Passali

Copyright © 2014 Anna Eitenmüller et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To investigate the tolerability and impact on quality of life of liposomal nasal spray compared to guideline-recommended steroid-based therapy in patients with chronic rhinosinusitis. Symptom reduction and use of antisymptomatic medication were also examined. Methods. In this monocenter, prospective, controlled, open, and noninterventional study, 60 patients with chronic rhinosinusitis were treated with liposomal nasal spray and 30 patients received steroid-based therapy. The study comprised five visits occurring at intervals of two to four weeks. Efficacy was determined according to the sinusitis symptom score documented daily. The polyp score was recorded at the initial and final visits. Tolerability was determined through the Nasal Spray Evaluation Questionnaire, and quality of life was ascertained with the SNOT-20 Score. Results. Both treatments achieved a significant reduction of sinusitis symptoms () and also rhinoscopic improvement (). The majority of patients assessed the treatments as “good” or “very good,” and the quality of life improved significantly (). There was no significant difference in symptom reduction, QoL, and endoscopic exams between both treatments. Conclusion. The treatment of chronic rhinosinusitis with liposomal nasal spray results in a similar, significant reduction of symptoms and significant improvement in quality of life as guideline-recommended treatment and is therefore a comparable alternative.