Table of Contents
Journal of Allergy
Volume 2014, Article ID 176597, 13 pages
http://dx.doi.org/10.1155/2014/176597
Clinical Study

Treatment of Allergic Rhinitis with Ectoine Containing Nasal Spray and Eye Drops in Comparison with Azelastine Containing Nasal Spray and Eye Drops or with Cromoglycic Acid Containing Nasal Spray

1Bitop AG, Stockumer Straße 28, 58453 Witten, Germany
2Private Health Centre, Institute for ENT Elmshorn, Hermann-Ehlers-Weg 4, 25337 Elmshorn, Germany

Received 10 February 2014; Accepted 29 March 2014; Published 1 June 2014

Academic Editor: Ralph Mösges

Copyright © 2014 Nina Werkhäuser et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. L. Broek, J. Bousquet, C. E. Baena-Cagnani et al., “Allergic rhinitis and its impact on asthma (ARIA) guidelines: 2010 revision,” Journal of Allergy and Clinical Immunology, vol. 126, no. 3, pp. 466–476, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. D. K. Sur and S. Scandale, “Treatment of allergic rhinitis,” American Family Physician, vol. 81, no. 12, pp. 1440–1446, 2010. View at Google Scholar · View at Scopus
  3. F. Horak and U. P. Zieglmayer, “Azelastine nasal spray for the treatment of allergic and nonallergic rhinitis,” Expert Review of Clinical Immunology, vol. 5, no. 6, pp. 659–669, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. “Disodium cromoglycate in allergic respiratory disease,” British Medical Journal, vol. 2, no. 5806, pp. 159–161, 1972.
  5. T. A. Mahr, “Therapy in allergic rhinoconjunctivitis: new horizons,” Allergy and Asthma Proceedings, vol. 28, no. 4, pp. 404–409, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. HealthSTAR Communications and Schulman Ronca & Bucuvales, Allergies in America: A Landmark Survey of Nasal Allergy Sufferers: Adult, 2006.
  7. C. E. Roehm, B. Tessema, and S. M. Brown, “The role of alternative medicine in rhinology,” Facial Plastic Surgery Clinics of North America, vol. 20, no. 1, pp. 73–81, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Passalacqua, P. J. Bousquet, K.-H. Carlsen et al., “ARIA update: I—systematic review of complementary and alternative medicine for rhinitis and asthma,” Journal of Allergy and Clinical Immunology, vol. 117, no. 5, pp. 1054–1062, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. E. A. Galinski, H.-P. Pfeiffer, and H. G. Truper, “1,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid. A novel cyclic amino acid from halophilic phototrophic bacteria of the genus Ectothiorhodospira,” European Journal of Biochemistry, vol. 149, no. 1, pp. 135–139, 1985. View at Google Scholar · View at Scopus
  10. E. Bremer and R. Krämer, “Coping with osmotic challenges: osmoregulation through accumulation and release of compatible solutes in bacteria,” in Bacterial Stress Responses, pp. 79–97, 2000. View at Google Scholar
  11. T. Arakawa and S. N. Timasheff, “The stabilization of proteins by osmolytes,” Biophysical Journal, vol. 47, no. 3, pp. 411–414, 1985. View at Google Scholar · View at Scopus
  12. Y. Oberdörfer, S. Schrot, H. Fuchs, E. Galinski, and A. Janshoff, “Impact of compatible solutes on the mechanical properties of fibronectin: a single molecule analysis,” Physical Chemistry Chemical Physics, vol. 5, no. 9, pp. 1876–1881, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. R. K. Harishchandra, S. Wulff, G. Lentzen, T. Neuhaus, and H.-J. Galla, “The effect of compatible solute ectoines on the structural organization of lipid monolayer and bilayer membranes,” Biophysical Chemistry, vol. 150, no. 1–3, pp. 37–46, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Bilstein, A. Salapatek, P. Patel, and G. Lentzen, “Topical treatments based on ectoine, a novel, non-drug, extremophile-based substance, relieves allergic rhinoconjunctivitis symptoms in patients in an environmental eexposure chamber model,” in Proceedings of the 30th Congress of the European Academy of Allergy and Clinical Immunology (EAACI '11), June 2011.
  15. B. Colagiuri, “Participant expectancies in double-blind randomized placebo-controlled trials: potential limitations to trial validity,” Clinical Trials, vol. 7, no. 3, pp. 246–255, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. F.-G. Pajonk, R. Holzbach, and D. Naber, “Evaluation of efficacy of neuroleptics in open versus double-blind trials,” Fortschritte der Neurologie Psychiatrie, vol. 68, no. 7, pp. 313–320, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. I. G. V. James, L. M. Campbell, J. M. Harrison, P. J. Fell, B. Ellers-Lenz, and U. Petzold, “Comparison of the efficacy and tolerability of topically administered azelastine, sodium cromoglycate and placebo in the treatment of seasonal allergic conjunctivitis and rhinoconjunctivitis,” Current Medical Research and Opinion, vol. 19, no. 4, pp. 313–320, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. W. Lumry, B. Prenner, J. Corren, and W. Wheeler, “Efficacy and safety of azelastine nasal spray at a dose of 1 spray per nostril twice daily,” Annals of Allergy, Asthma and Immunology, vol. 99, no. 3, pp. 267–272, 2007. View at Google Scholar · View at Scopus
  19. S. Shah, W. Berger, W. Lumry, C. la Force, W. Wheeler, and H. Sacks, “Efficacy and safety of azelastine 0.15% nasal spray and azelastine 0.10% nasal spray in patients with seasonal allergic rhinitis,” Allergy and Asthma Proceedings, vol. 30, no. 6, pp. 628–633, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. W. C. Howland, N. J. Amar, W. Wheeler, and H. Sacks, “Efficacy and safety of azelastine 0.15% nasal spray administered once daily in patients with allergy to Texas mountain cedar pollen,” International Forum of Allergy & Rhinology, vol. 1, no. 4, pp. 275–279, 2011. View at Google Scholar
  21. J. van Bavel, W. C. Howland, N. J. Amar, W. Wheeler, and H. Sacks, “Efficacy and safety of azelastine 0.15% nasal spray administered once daily in subjects with seasonal allergic rhinitis,” Allergy and Asthma Proceedings, vol. 30, no. 5, pp. 512–518, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. N. Falser, W. Wober, V. W. Rahlfs, and M. Baehre, “Comparative efficacy and safety of azelastine and levocabastine nasal sprays in patients with seasonal allergic rhinitis,” Arzneimittel-Forschung, vol. 51, no. 5, pp. 387–393, 2001. View at Google Scholar · View at Scopus
  23. D. Charpin, P. Godard, R. P. Garay, M. Baehre, D. Herman, and F. B. Michel, “A multicenter clinical study of the efficacy and tolerability of azelastine nasal spray in the treatment of seasonal allergic rhinitis: a comparison with oral cetirizine,” European Archives of Oto-Rhino-Laryngology, vol. 252, no. 8, pp. 455–458, 1995. View at Publisher · View at Google Scholar · View at Scopus
  24. P. H. Ratner, P. M. Ehrlich, S. M. Fineman, E. O. Meltzer, and D. P. Skoner, “Use of intranasal cromolyn sodium for allergic rhinitis,” Mayo Clinic Proceedings, vol. 77, no. 4, pp. 350–354, 2002. View at Google Scholar · View at Scopus
  25. D. E. Schuller, J. E. Selcow, T. H. Joos et al., “A multicenter trial of nedocromil sodium, 1% nasal solution, compared with cromolyn sodium and placebo in ragweed seasonal allergic rhinitis,” Journal of Allergy and Clinical Immunology, vol. 86, no. 4, pp. 554–561, 1990. View at Google Scholar · View at Scopus
  26. E. O. Meltzer, “Efficacy and patient satisfaction with cromolyn sodium nasal solution in the treatment of seasonal allergic rhinitis: a placebo-controlled study,” Clinical Therapeutics, vol. 24, no. 6, pp. 942–952, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. P. Patel, C. D'Andrea, and H. J. Sacks, “Onset of action of azelastine nasal spray compared with mometasone nasal spray and placebo in subjects with seasonal allergic rhinitis evaluated in an environmental exposure chamber,” American Journal of Rhinology, vol. 21, no. 4, pp. 499–503, 2007. View at Publisher · View at Google Scholar · View at Scopus