Research Article
Possible Mechanism of Action of the Antiallergic Effect of an Aqueous Extract of Heliotropium indicum L. in Ovalbumin-Induced Allergic Conjunctivitis
Figure 5
Photomicrographs of the conjunctival tissues in OIAC in guinea pigs treated with 30, 100, and 300 mg kg−1 HIE, 30 mg kg−1 prednisolone, 10 mg kg−1 chlorpheniramine, and PBS, compared to that of normal guinea pigs.
(a) Normal conjunctival tissue with normal epithelial architecture without evidence of mononuclear infiltration |
(b) 30 mg kg−1 prednisolone treated with mild mononuclear infiltration into the subepithelial tissue of the conjunctiva |
(c) PBS-treated conjunctival tissue with widespread infiltration of neutrophils and eosinophils |
(d) 10 mg kg−1 chlorpheniramine treatment with remarkably unresolved inflammatory process seen as intense polymorphonuclear infiltration |
(e) 30 mg kg−1 HIE treated with mild infiltration of neutophilic and eosinophilic cells |
(f) 100 mg kg−1 HIE treated conjunctival tissue with moderately diffuse neutrophils and eosinophils exudation |
(g) 300 mg kg−1 HIE treated with mild neutophils and eosinophil infiltration in subepithelial conjunctival tissue |