Table of Contents
Journal of Allergy
Volume 2015, Article ID 312052, 7 pages
Review Article

Omega-3 Fatty Acids Supplementation in Children to Prevent Asthma: Is It Worthy?—A Systematic Review and Meta-Analysis

1Department of Paediatrics, S.B.K.S MIRC, Sumandeep Vidyapeeth, Vadodara, Gujarat 391760, India
2Department of Periodontics, K.M.S DCH, Sumandeep Vidyapeeth, Vadodara, Gujarat 391760, India
3Department of Medicine, S.B.K.S MIRC, Sumandeep Vidyapeeth, Vadodara, Gujarat 391760, India

Received 23 May 2015; Revised 4 August 2015; Accepted 6 August 2015

Academic Editor: Stephen P. Peters

Copyright © 2015 Prasad Muley et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Asthma is one of the most common respiratory diseases affecting all age groups. The world is now trying to identify some dietary factors which can play a preventive role. We performed this systematic review and meta-analysis of RCTs to assess the effect of intake of polyunsaturated fatty acid (PUFA) in infancy and/or childhood on incidence of asthma or wheezing episodes. We searched MEDLINE, EBSCO, Trip, and Google Scholar up to January 31, 2015. All RCTs where infants or children who were given omega-3 fatty acid supplementation and which reported incidence of asthma and/or wheezing episodes as dichotomous outcomes were included in this review. Random effects model was used for pooling the risk estimates. Total five articles were included. Most of them were from Australia. On meta-analysis, the pooled estimate of odds ratios by random effects model showed no significant change in incidence of asthma after supplementation of omega-3 FA in infancy or childhood (OR 0.974; CI 0.646, 1.469; ). We concluded that a multicentric RCT is required to assess the effect of omega-3 FA supplementation exclusively to infants or children to predict the best time of omega-3 FA supplementation to prevent asthmatic or wheezing episodes later in life.