Journal of Allergy

Aspirin Exacerbated Respiratory Disease


Publishing date
18 May 2012
Status
Published
Submission deadline
30 Dec 2011

Lead Editor

1Department of Immunogenetics and Allergy, National Institute of Respiratory Diseases, Mexico City, DF, Mexico

2Division of Infection, Inflammation and Immunity, School of Medicine, University of Southampton, Southampton, UK

3Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Republic of Korea


Aspirin Exacerbated Respiratory Disease

Description

Aspirin exacerbated respiratory disease (AERD) is characterized by chronic inflammation of the upper and lower respiratory tract and affects both nonatopic and atopic subjects. This clinical syndrome is a combination of chronic rhinosinusitis progressing to chronic hyperplastic sinusitis, moderate-to-severe asthma, nasal polyposis, and aspirin intolerance. The mechanisms of aspirin sensitivity remain unclear, but most studies conclude that aspirin causes the inhibition of cyclooxygenase-1 (COX-1), shunting arachidonic acid metabolism towards an overproduction of cysteinyl-leukotrienes (cys-LTs) while there is a rapid decrease in the synthesis of COX-1 products including prostaglandin E2. Moreover, an extensive infiltration of eosinophils and mast cells takes place into the airways of aspirin-sensitive patients. Genetic studies have shown that a single-nucleotide polymorphism (SNP) 444 nucleotides upstream of the translational start site (–444A/C) in the promoter region of the LTC4S gene correlates with aspirin sensitivity in severe steroid-dependent AERD in both European and Japanese patients. However, this SNP is only weakly associated with asthma and not at all with AERD in other populations. The HLA DPB1*0301 has been found associated with AERD in Korean population.

Authors are invited to submit either original research manuscripts or review articles which may help to understand the mechanism of AERD. Potential topics include, but are not limited to:

  • Mechanism(s) involved in cyclooxygenase inhibition by aspirin
  • Identification of the cellular site of COX inhibition and the relative involvement of COX-1 and COX-2 isozymes
  • Advances in the identification of genes which influence AERD
  • Immunological changes associated with AERD
  • The role of respiratory viruses in the development of AERD
  • Identification of new biomarkers for early diagnosis
  • Defining the mechanism(s) of desensitization with aspirin in the improvement of chronic disease and severity
  • New therapies for AERD

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ja/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 473863
  • - Editorial

Aspirin Exacerbated Respiratory Disease

Luis M. Teran | Stephen T. Holgate | ... | Anthony P. Sampson
  • Special Issue
  • - Volume 2012
  • - Article ID 817910
  • - Review Article

Aspirin Sensitivity and Chronic Rhinosinusitis with Polyps: A Fatal Combination

Hendrik Graefe | Christina Roebke | ... | Jens Eduard Meyer
  • Special Issue
  • - Volume 2012
  • - Article ID 273752
  • - Review Article

Rhinosinusitis and Aspirin-Exacerbated Respiratory Disease

Maria L. Garcia Cruz | M. Alejandro Jimenez-Chobillon | Luis M. Teran
  • Special Issue
  • - Volume 2012
  • - Article ID 789232
  • - Review Article

Pathogenic Mechanisms and In Vitro Diagnosis of AERD

Dirk Schäfer | Steffen Maune
  • Special Issue
  • - Volume 2012
  • - Article ID 696792
  • - Research Article

Exhaled Eicosanoids following Bronchial Aspirin Challenge in Asthma Patients with and without Aspirin Hypersensitivity: The Pilot Study

L. Mastalerz | M. Sanak | ... | A. Szczeklik
  • Special Issue
  • - Volume 2012
  • - Article ID 182090
  • - Review Article

Interleukin-4 in the Generation of the AERD Phenotype: Implications for Molecular Mechanisms Driving Therapeutic Benefit of Aspirin Desensitization

John W. Steinke | Spencer C. Payne | Larry Borish
  • Special Issue
  • - Volume 2012
  • - Article ID 580873
  • - Research Article

Comparison of CD63 Upregulation Induced by NSAIDs on Basophils and Monocytes in Patients with NSAID Hypersensitivity

N. Abuaf | H. Rostane | ... | R. Girot
  • Special Issue
  • - Volume 2012
  • - Article ID 741313
  • - Research Article

The IL1B-511 Polymorphism (rs16944 AA Genotype) Is Increased in Aspirin-Exacerbated Respiratory Disease in Mexican Population

Ramcés Falfán-Valencia | Gandhi F. Pavón-Romero | ... | Luis Manuel Teran
  • Special Issue
  • - Volume 2012
  • - Article ID 348741
  • - Research Article

Interleukin-13, but Not Indomethacin, Increases Cysteinyl-Leukotriene Synthesis in Human Lung Macrophages

Sarah E. Jackson | John W. Holloway | ... | Anthony P. Sampson
  • Special Issue
  • - Volume 2012
  • - Article ID 794890
  • - Review Article

Genetic Mechanisms in Aspirin-Exacerbated Respiratory Disease

Nami Shrestha Palikhe | Seung-Hyun Kim | ... | Hae-Sim Park

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.