Table of Contents
Journal of Amino Acids
Volume 2010 (2010), Article ID 346237, 5 pages
http://dx.doi.org/10.4061/2010/346237
Clinical Study

Pharmacokinetics of Oral Taurine in Healthy Volunteers

1NPMC, Hemmatology and Oncology Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran
2Tropical and Infectious Diseases Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran
3Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
4Department of Pharmacology and Therapeutics, College of Medicine, Cardiff University, Heath Park, Cardiff, UK

Received 23 November 2009; Revised 9 March 2010; Accepted 20 May 2010

Academic Editor: Hari S. Sharma

Copyright © 2010 Mohammadreza Ghandforoush-Sattari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Taurine, a sulfur-containing amino acid, is a normal constituent of the human diet. Little is known of the pharmacokinetics of taurine in man after oral administration. We studied the pharmacokinetics of 4 g taurine in eight healthy male volunteers (median age 27.5, range 22–45) following orally administration in the fasting state in the morning. Blood samples were taken at regular intervals and plasma taurine concentration was measured by a modified HPLC method. Data were subjected to noncompartmental analysis. Maximum plasma taurine concentration ( C m a x ) was measured at 1 . 5 ± 0 . 6  hr after administration as 8 6 . 1 ± 1 9 . 0  mg/L ( 0 . 6 9 ± 0 . 1 5  mmol). Plasma elimination half-life ( T 1 / 2 ) and the ratio of clearance/bioavailability (Cl/F) were 1 . 0 ± 0 . 3  hr and 2 1 . 1 ± 7 . 8  L/hr, respectively. Since taurine is occasionally used in therapeutics as a medicine, the pharmacokinetics and effects of oral taurine in healthy volunteers would be useful in the future studies of taurine in pharmacology and nutrition.