Serpin Inhibition Mechanism: A Delicate Balance between Native Metastable State and Polymerization
Figure 4
Point mutation in representative serpins that leads to latency, dimerization, aggregation and polymerization. Figure shows different serpin members like antithrombin (1e05), α-1 antitrypsin (2qug), neuroserpin (1jjo), antichymotrypsin (4caa), heparin cofactor-II (1jmj) and C1-inhibitor along with corresponding natural variant that gives rise to polymerization. Images were prepared by using Pymol visualization tool.
