Serpin Inhibition Mechanism: A Delicate Balance between Native Metastable State and Polymerization

Represents the Scissile bond in various serpins and their protease targets.  Antithrombin is an efficient inhibitor of factor Xa, thrombin and factor IXa.  Residues flanking the P1-P1′ are also critical for protease multispecificity.

Journal of Amino Acids

tab1

Table 1

Table 1: Serpin Inhibition Mechanism: A Delicate Balance between Native Metastable State and Polymerization 