Functional Subunits of Eukaryotic Chaperonin CCT/TRiC in Protein Folding

Figure 2

Comparison of highly conserved ATP binding/hydrolysis motifs in equatorial domain. GroEL, chaperonin of E. coli; Cct1p-Cct8p subunits of CCT complex of yeast S. cerevisiae; Cctα-hu, Cct1α subunit from human and Thr-β, β subunit from Acidianus tengchongensis. Starting from E. coli (homooligomeric chaperonin) to human (heterooligomeric chaperonin), all the chaperonin subunits have maintained conserved regions and any changes would have severe effects.