Table of Contents
Journal of Amino Acids
Volume 2012, Article ID 206520, 8 pages
Review Article

Environmental Factors Preceding A 𝜷 40 Monomer to Oligomers and the Detection of Oligomers in Alzheimer's Disease Patient Serum

Department of Medical Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan

Received 11 August 2011; Revised 20 October 2011; Accepted 27 October 2011

Academic Editor: Jianning Wei

Copyright © 2012 Yoichi Matsunaga and Midori Suenaga. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We present here environmental factors including pH shifts, temperature, and metal ions surrounding Aβ40 monomer to precede the oligomers. We also suggest a new idea to detect Aβ40 oligomers with anti-Aβ40 monoclonal antibody using enzyme-linked immunosorbent assay. This method involves the different sensitivity of the thermal shifts between Aβ40 monomer and the oligomers. The idea is useful for the diagnostics of Alzheimer's disease to detect Aβ40 oligomers in the serum from the patients.