Table of Contents
Journal of Amino Acids
Volume 2013, Article ID 183421, 12 pages
http://dx.doi.org/10.1155/2013/183421
Review Article

Cdc48: A Swiss Army Knife of Cell Biology

1Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
2The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330006, China

Received 31 May 2013; Revised 29 July 2013; Accepted 12 August 2013

Academic Editor: Heather M. Wallace

Copyright © 2013 Guem Hee Baek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cdc48 (also called VCP and p97) is an abundant protein that plays essential regulatory functions in a broad array of cellular processes. Working with various cofactors, Cdc48 utilizes its ATPase activity to promote the assembly and disassembly of protein complexes. Here, we review key biological functions and regulation of Cdc48 in ubiquitin-related events. Given the broad employment of Cdc48 in cell biology and its intimate ties to human diseases (e.g., amyotrophic lateral sclerosis), studies of Cdc48 will bring significant insights into the mechanism and function of ubiquitin in health and diseases.